Dr. Yan is a well-known computational biologist and bioinformatician. She is interested in genetics, genomics, computational biology, biostatistics, system biology and bioinformatics. Her current research topics include (1) understanding disease heterogeneity and pathogenesis using large-scale omics data including bulk, single-cell and spatial trancstiptomic data, and (2) developing novel statistical and computational methods for analyses of different types of large-scale omics data and the integration of them with drug perturbation data for potential personalized treatment design.